For treating hematopoietic subsyndrome of acute radiation syndrome radiation sickness , Neulasta is given as two doses. A single dose is one injection with the syringe. For Neulasta dosages in children who weigh more 99 pounds 45 kg , see the dosage sections above. Dosages for children who weigh less than 99 pounds 45 kg are based on weight.
If you miss giving yourself an injection of Neulasta with a syringe, call your doctor as soon as you realize this. They can advise you on when you take your dose. The staff can reschedule you and adjust the timing of future visits, if necessary. This is because the on-body injector can sometimes fail to work or leak. The staff will schedule a time for you to come in for a Neulasta injection so that you receive your full dose.
You can also write your treatment schedule in a calendar. For preventing infections during chemotherapy, Neulasta is meant to be used as a long-term treatment. Neulasta works by triggering your immune system to make more white blood cells. Certain proteins called histamines are also released by this process. But research has shown that histamine is involved in inflammation , which can cause pain.
Claritin is an antihistamine medication. It works by blocking the action of histamine. By doing so, Claritin may help reduce bone pain in people taking Neulasta, but more research is needed. They can review available treatments and help determine which one is best for you. In clinical studies , some people reported bone pain or pain in their arms or legs after receiving Neulasta. You can also reach out to your doctor.
The timing can vary. Clinical studies showed that clearing Neulasta from the body is affected by your body weight and the number of neutrophils a type of white blood cell present in your blood.
In general, after one injection, Neulasta is completely eliminated from your system within 14 days. The manufacturer of Neulasta has a Transportation Security Administration TSA notification card that you can print and present to security personnel at the airport. Click here to access the card. The device is dispensing the drug into your body during this time. And traveling may increase the risk of Neulasta Onpro getting knocked off your body. The signals from these electrical devices may interfere with Neulasta Onpro and keep it from providing your dose.
This is offered at no additional cost to you. Neulasta is typically used with other drugs. This is because Neulasta is only one part of a cancer treatment regimen plan.
Neulasta is commonly used with chemotherapy because Neulasta helps prevent or treat side effects of chemotherapy. Keep in mind that this is not a full list of chemotherapy medications.
Talk with your doctor if you have questions about any chemotherapy drugs and whether Neulasta might benefit you. Other drugs are available that can treat your condition. Some may be a better fit for you than others. They can tell you about other medications that may work well for you. Note : Some of the drugs listed below are used off-label to treat these specific conditions.
Examples of other drugs that may be used to help prevent infections during chemotherapy include:. Examples of other drugs that may be used to treat radiation sickness include:. You may wonder how Neulasta compares with other medications that are prescribed for similar uses.
Here we look at how Neulasta and Granix are alike and different. Both pegfilgrastim and tbo-filgrastim belong to a class of medications known as granulocyte-colony stimulating factors G-CSFs. A medication class is a group of drugs that work in a similar way. A G-CSF is a medication that causes neutrophils a type of white blood cell to grow in your bone marrow. Bone marrow is the tissue inside bones that makes blood cells.
Both Neulasta and Granix are approved by the Food and Drug Administration FDA to reduce the risk of infection due to a condition called febrile neutropenia in people with non-myeloid cancers. Neulasta is also FDA-approved to treat radiation sickness. Granix also comes in two forms: a single-dose prefilled syringe and a single-dose vial of liquid solution. Both forms can be given by a healthcare provider as an injection subcutaneously, directly under your skin.
But with some training, you may be able to give yourself injections at home. One important difference between Neulasta and Granix is how often the drugs are given to reduce the risk of infection during chemotherapy. Neulasta is given only once during each chemotherapy cycle. Granix, on the other hand, is given every day until the levels of neutrophils in your blood return to normal.
Neulasta and Granix are both used to help prevent infections during chemotherapy. Therefore, these medications can cause some similar side effects, but some different ones as well. Below are examples of these side effects. These lists contain examples of mild side effects that can occur with Neulasta, with Granix, or with both drugs when taken individually. These lists contain examples of serious side effects that can occur with Neulasta, with Granix, or with both drugs when taken individually.
The only use both Neulasta and Granix are approved for is reducing the risk of infection due to a condition called febrile neutropenia in people with non-myeloid cancers.
Separate studies of the two drugs were compared in a larger review of studies called a systemic review. Researchers looked at data from 18 studies. People had received pegfilgrastim the active drug in Neulasta , filgrastim, or a similar drug, including Granix.
The pegfilgrastim group was less likely to develop febrile neutropenia and less likely to require a hospital stay as a result of febrile neutropenia. This was compared with the other drug groups. According to estimates on GoodRx.
Like Granix discussed above , the drug Fulphila has uses similar to those of Neulasta. Technically, Fulphila contains the active ingredient pegfilgrastim-jmdb. This is because Fulphila is a type of drug known as a biosimilar. In this case, Neulasta is the biologic drug, and Fulphila is the biosimilar of it.
Pegfilgrastim and pegfilgrastim-jmdb both work in the same way. Pegfilgrastim belongs to a class of medications known as granulocyte-colony stimulating factors G-CSFs. A class of medications is a group of drugs that work in a similar way.
Both Neulasta and Fulphila are approved by the Food and Drug Administration FDA to reduce the risk of infection due to a condition called febrile neutropenia in people with non-myeloid cancers. Both Neulasta and Fulphila come as a single-dose prefilled syringe. A healthcare provider will give you the Neulasta or Fulphila injection, or you may be able to give yourself the injection at home after being trained.
Neulasta and Fulphila both contain pegfilgrastim. Therefore, these medications can cause very similar side effects. This list contains examples of mild side effects that can occur with Neulasta and Fulphila when taken individually :. This list contains examples of serious side effects that can occur with Neulasta and Fulphila when taken individually :.
The only use both Neulasta and Fulphila are approved for is reducing the risk of infection due to a condition called febrile neutropenia in people with non-myeloid cancers. Many typical drugs that are made from chemicals have generic versions. A generic drug is an exact copy of the active ingredient in a brand-name medication. It often costs less than the brand-name version. However, Neulasta and Fulphila are both brand-name biologic drugs, which are created from parts of living organisms.
Instead of generics, biologic drugs have biosimilars. So Fulphila is a biosimilar of Neulasta. Neulasta helps reduce the risk of infection due to a condition called febrile neutropenia in people with non-myeloid cancers. It may also be referred to as acute radiation syndrome. Granulocyte-colony stimulating factor G-CSF is a hormone that causes neutrophils to grow in your bone marrow. The active drug in Neulasta, pegfilgrastim, is a man-made copy of the G-CSF hormone your body makes naturally.
Pegfilgrastim works in the same exact way that natural G-CSF does. This helps your body be more prepared to fight infections, prevent febrile neutropenia, and shorten how long you have neutropenia. For hematopoietic subsyndrome due to radiation sickness, Neulasta helps your body replace white blood cells that were destroyed in the bone marrow by radiation exposure. However, clinical studies show that it may take 1 to 2 weeks for your neutrophil levels to return to normal after you receive a dose of Neulasta following a round of chemotherapy.
When used for radiation sickness, it may take several days for Neulasta to help your body replace white blood cells that were destroyed. However, alcohol may interfere with some chemotherapy drugs or make their side effects worse. Talk with your doctor about whether alcohol is safe for you to drink during your chemotherapy treatment. Neulasta is given after a dose of chemotherapy. This is because no formal studies have been done to detect drug interactions.
Based on how the drug works, interactions with other medications are unlikely. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
However, you should still check with your doctor or pharmacist before using any of these products while taking Neulasta. If you have any questions about eating certain foods while taking Neulasta, talk with your doctor.
As with all medications, the cost of Neulasta can vary. To find current prices for Neulasta in your area, check out GoodRx. The cost you find on GoodRx. This type of pharmacy is authorized to carry specialty medications. These are drugs that may be expensive or may require help from healthcare professionals to be used safely and effectively.
It is classified as a colony stimulating factor. For more detail, see "How this drug works" section below. Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful. Not all side effects are listed above. However, you should always inform your health care provider if you experience any unusual symptoms.
Contact your health care provider immediately , day or night, if you should experience any of the following symptoms:. The following symptoms require medical attention, but are not emergency situations. Contact your health care provider within 24 hours of noticing any of the following:.
Always inform your health care provider if you experience any unusual symptoms. You will be checked regularly by your doctor while you are taking pegfilgrastim to monitor side effects and check your response to therapy. These effects are called interactions. Before taking Neulasta, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. Also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Neulasta.
If you have any questions about possible interactions with Neulasta, talk with your doctor or pharmacist. Neulasta may not be right for you if you have certain medical conditions or other factors that affect your health.
Talk with your doctor about your health history before you take Neulasta. Factors to consider include those in the list below. But, alcohol could worsen some side effects of certain chemotherapy drugs.
And Neulasta is commonly used with chemotherapy. Using more than this can lead to serious side effects. You can also call to reach the American Association of Poison Control Centers, or use their online resource.
If you have severe symptoms, immediately call or your local emergency number, or go to the nearest emergency room. If you have radiation sickness or take chemotherapy drugs that increase your risk for serious infection , your doctor may recommend Neulasta.
You can learn more about ways to prevent infections in this article. See this article to read more about new chemotherapy options with fewer side effects. If you have questions about Neulasta, talk with your doctor or pharmacist. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional.
You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
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Medically reviewed by Seunggu Han, M. Medically reviewed by Shilpa Amin, M. Medically reviewed by Yamini Ranchod, Ph.
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